So here we are on the 2nd dose. After being ingested by a dog, sarolaner is distributed throughout the body. Just wondering? He also lashes at me with his teeth. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. I am going to try stopping the medication for a month to see if things improve. She has episodes where she seems very anxious and is hiding under car/tables/beds. So, I gave it to him. I also lost my dog due to simparia Trio. The more we complain the more chance we have of saving other dogs. We just brought him home from hospital today. The reaction lasted less than 12 hours. My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. It's only available with a prescription from your veterinarian, so you cannot get it over-the-counter. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). She seems to have aged five years since T-Day. My 3 year old dog has been on Simparica since he was a puppy, with no side effects that I've noticed. Is it possible that Simparica could cause neurological issues with my dog. So far, the cost of diagnostic tests are about $700. My personal dog has had no issues at all, and she's been on it for nearly two years. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! After reading all these reports I am convinced this is the reason our baby is so sick. Gave it to my dog on Thursday night and Sat stools were soft. Sorry but keeping it caged due to a suspected side effect is is uncalled for. After second pill, weve notice he has been a bit down for a couple days. My other Lab after 5 days started having severe diaherria (black at first, now golden) and now throwing up too. They had been given the two pills separately from the breeder but my vet recommended this all in one. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. She is scared of her own shadow, walks into things at times, trips and stumbles, has become very timid, stares at the wall and has to have either me or my husband in sight at all times. They had no clue what had happened so again we took him to the er and he checked out fine. Then we seen an ad on tv for Simparica and it mentioned seizures as a side effect. How long did it last with your dog? So no Addisions. Previously B was on Heartgard and Advantix worked well I guess we switch back. I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . 13 March he is also very lethargic and sitll not eating (even his favorite treats). Has anyone else experienced this? Product Information: Simparica Trio (sarolaner, moxidectin, and pyrantel) Chewables are a safe monthly chewable for dogs that prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworms and . I'm so sorry. It has been five days and the diarrhea started on day 2. This is worth the cost to buy a six-pack of protection. I realized he had no control over his body . Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. . He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. Now we are waiting for the verdict: whether its an infection in his bladder or stones. The cardiologist found no heart condition that would cause this. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. At first B seemed fine. Then I saw this and realized. Any suggestion? We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. Within 24 hours, he would not leave my bedroom, slept all day, no appetite. Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. She became very neurotic, so many changes in her personality and she became very anxious her first and only dose was in November 2020 she never returned to the special dog that we had and she passed in March 2021 at 8 years old. Took him to the vet Potassium level was so high they did an ekg and his heart was not beating regular. Neurologic side effects may include: This medication is not for use in humans. Certain age, breed predispositions. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. He has been on just Simparica with no problems. Please do NOT use it!! Mine is. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. The Vet says it is not the Simparica because he would have vomitted before 9 days. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. Didnt notice anything with first dose. He is eating fine with no diarrhea or vomiting. Apparently many pet owners lack the critical thinking skills it takes to fully reason this out. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. I'm not going to make her a test case by giving her another dose next month. This is just another reason to follow your vet's recommendations for annual physical exams and tests. I called the manufacturer (Zoetis) and filed a report, immediately discontinued the tablets and started to detox him. She has been the healthiest, happiest dog. You ask why they are giving this poison to our furbabies, it's easy. How is ur puppy? Just our own personal experience but I won't get burned again! All Rights Reserved. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. Nothing they can do for her she said. I was furious with the drug and the prescriber too. Hope all is well. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. I regret putting her on this drug. He has been eating the same organic GF food for the past several years. Im praying over him too . like what??? Will this ever get better as the med wears down? He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). I just started my 80 pound pit on this same medication yesterday. Bella is a very anxious dog and is my husbands shadow. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. This junk needs to be pulled from the market. He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. He ran bloods and sent her home with Keppra three times a day, after two weeks she is now down to twice a day. The older of the 2 Poodles seemed to do fine but my younger Poodle who was about 3 years old was definitely affected and we had a difficult time even getting him to eat for at least 2 weeks. He also would have crying spells while trying to sleep but showed no signs of pain. Has anyone experienced cardiac issues while under anesthesia on this medication? This medication must really be strong to do Flea tic and heart worm etc. He seems back to his normal self and playing with his toys, but we will not continue the following doses! Has odd agitated swallowing when not eating anything. Before sharing sensitive information, make sure you're on a federal government site. A few hours later, he began vomiting nonstop. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. This seemed like perfect treatment 3 in 1 but at what cost? I gave my dog his first dose the first week of April. My dog is on a "health care plan" with my vet. The FDA considers this level to be "very rare". No simparica for them either! How long do the side effects last? I originally wanted to get Nexgard, but for some odd reason, when I had went to my vet to pick it up, instead they gave me this. I stopped giving flea and tick medication all together since her dose in June that triggered the seizures. I gave it to her then I looked at the box that said never tested on pregnant dogs . He hasn't eaten since and grazes on grass like he is a goat. Its now about May 16th 2021. But anyways - the other night , his feet collapsed from under him & he fainted . Prednisone helped symptoms in our case but the seizures kept going even after stopping this horrible med. So bad that the FDA made them put a huge warning now on the package. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. His blood work came back normal but the vet called me to ask if his simparica somehow coincided with time of the seizures. Did you do this yourself or let the vet? So your dog got better? Today is Friday. 98. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. Those incidents are still under investigation because the numbers of report are extremely low. All they care about is the money and not the animal. Don't trust your vet, do your own research. I have to turn him around and lead him away. No more of this junk for my pups! We wont be using this medicine ever again! And for those who have lost their fur babies I am so sorry for your lost. But today she isnt eating well, had a bout of diarrhoea and is very tired. He is otherwise normal and healthy. Your pets condition worsens or does not improve with treatment, You have additional questions or concerns about the use of Simparica or Simparica Trio. They drew blood & took a fecal sample . Be aware! Sold as 1 Month, 3 Month or 6 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs. It still makes me sick to think about her last month we miss her so much. Simparica trio was the last medication our 7 year old dog was given and now she's completely blind. Today really soft stool (not diarrhea but close). Are there any side effects to Simparica Trio? Our miniature schnauzer has been extremely thirsty and itchy to the point of biting until he bleeds. four times. My 5 year old Fox Hound isnow drinking lots of water and urinating in the house! After about a week, she started to improve. Hello! The results are fatal for fleas and ticks but safe for mammals such as your dog. The vet suggested this medication for my 9+ yr old English Bulldog. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. Next day, he was suddenly 1000% worse, would not touch food, could not move. Now, here we are one month later and I just gave him the second dose about two hours ago. Gave my Olde English Bulldog puppies Simparica Trio on 4/7/21 they are almost 4 month now. 38 results for "simparica trio for dogs" RESULTS. I started giving my aussie shepherd simparica at 4 months. . What are the side effects of Simparica Trio Chewable Tablets for Dogs? For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. I had always thought how can something so lethal to fleas an ticks be safe to ingest? Coton de Tulear. If she comes out of this I will return to heartworm pills and topical flea and tick meds. Vet thought was inner ear infection now thinking otherwise. Those with Diarrhea symptom, did it look like mucus in their pets stool? In other words, they can make it easier to have a seizure in susceptible dogs. My nearly 14 year old Havanese Kokomo has taken a sharp decline in the last 8 month and I was blaming it on old age when I think I may have been poisoning him. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. I realized it was from the simparica. He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. He has been barking a lot more than he used to. Like many of you, I was unsure about the cause. My vet recommended Simparica Trio for both my dogs (13 year old healthy Collie mix 7 lb chihuahua mix). Im beside myself. I wish I would have read these comments first. We did not make the connection until today. The vet suggested Simparico trio . A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. Used my own intuition and knowledge to make a good choice for my pet .good luck to everyone one here ! They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. Trifexis is much safer and I really don't care about the ticks - I can pull those off. My dogs have been throwing up since then and I could not for the life of me figure out why. Thanks all for sharing your experiences. It seemed impossible that our boy could age years in literally 3 days. He also got that odd cough here and there that I read someone else mention. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . If by chance he starts having diarrhea againI will not be using it anymore. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. I let him back in the bedroom yesterday all went well, then this morning I woke to him peeing in the floor again. Anyone else have the same eye issues? After reading all these posts that sound so similar to what we are going through. To report suspected adverse drug events for these products and/or obtain a copy of the Safety Data Sheet (SDS) or for technical assistance, contact the appropriate manufacturers at the following phone numbers: Merck Animal Health (Bravecto): 800-224-5318, Elanco Animal Health (Credelio): 888-545-5973, Boehringer Ingelheim (Nexgard): 888-637-4251, Zoetis (Simparica, Revolution Plus): 888-963-8471, If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see, Pet owners and veterinarians who have additional questions can contact. The vet office called simparica hotline to find out if it was safe to give her another one. Hi Laura, How is you pup doing one after getting off simparica? I switched all three of my dogs to simparica trio and ironically my one that is a simi feral h/w+ hound disappeared. Strictly natural with zero side effects from now on. Do not give extra or double doses. Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. I was giving my 70 lb golden doodle Trifexus, for nearly 2 years until suddenly he refused to eat it. We are now back to regular vet with bloodwork every two weeks and still on meds and diarrhea but not as bad. Our dog was killed by this poison within 15 hours after taking one dose. So from what I understand, your dog was on this for 6 months and got the serious symptoms after that? I thought it was just her aging but now I think it al started when she started this medication. I've beaten myself up so much giving her this drug, I felt I could trust the vet and the drug company but we obviously cant and it's all about making more money. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. After 9 days he began vomitting, even water, and mouth chattering like he was scared. Never had them ever and she's only 3 1/2 yrs old. Will be back at PetSmart on Monday. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. We are experiencing the same thing. Use with caution in dogs with a history of seizures. It was the first time she had taken Simparica. And yeah he ate today 4 chicken breast and appeared to want it even better. He took simparica trio 3 weeks ago and I cant wait until its out of his system! These are the side effects that were observed: Most common is vomitting Weakness and lethargy Soft stools Loss of appetite I gave my 15 year old dog this medicine. I say yes! . Normal. Company asked us to do diagnostic testing at vet.

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